Painless Tattoos Developed – Easy, Do-It-Yourself Microneedle Patches

Scientists Develop Painless Tattoos That Can Be Self-Administered

Imagine getting painlessly tattooed by a skin patch containing microscopic needles, instead of sitting in a tattoo chair for hours enduring painful punctures. Researchers at the Georgia Institute of Technology (Georgia Tech) have developed low-cost, painless, and bloodless tattoos that can be self-administered. They have many applications, from medical alerts to tracking neutered animals to cosmetics.

“We’ve miniaturized the needle so that it’s painless, but still effectively deposits tattoo ink in the skin,” said Mark Prausnitz, principal investigator on the paper. “This could be a way not only to make medical tattoos more accessible, but also to create new opportunities for cosmetic tattoos because of the ease of administration.”

Prausnitz presented the research in the journal iScience on September 14, with co-author Song Li, a former Georgia Tech postdoctoral fellow. Prausnitz is Regents’ Professor and J. Erskine Love Jr. Chair in the School of Chemical and Biomolecular Engineering.

Tattoos are used in medicine for multiple purposes. These include covering up scars, guiding repeated cancer radiation treatments, or restoring nipples after breast surgery. Tattoos can also be used instead of bracelets as medical alerts to communicate serious medical conditions such as epilepsy, diabetes, or allergies.

Various cosmetic products using microneedles are already on the market — mostly for anti-aging. However, developing microneedle technology for tattoos is new. Prausnitz is a veteran in this area. He has studied microneedle patches for years to painlessly administer drugs and vaccines to the skin without the need for hypodermic needles.

“We saw this as an opportunity to leverage our work on microneedle technology to make tattoos more accessible,” Prausnitz said. “While some people are willing to accept the pain and time required for a tattoo, we thought others might prefer a tattoo that is simply pressed onto the skin and does not hurt.” 

Transforming Tattooing

Tattoos generally use large needles to puncture repeatedly into the skin to get a good image. It is a time-consuming and painful process. The Georgia Tech team has developed microneedles that are smaller than a grain of sand and are constructed of tattoo ink encased in a dissolvable matrix.

“Because the microneedles are made of tattoo ink, they deposit the ink in the skin very efficiently,” said Li, the lead author of the study.

In this way, the microneedles can be pressed into the skin just once and then dissolve. They leave the ink in the skin after a few minutes without bleeding.  

Tattooing Technique

Although most microneedle patches for pharmaceuticals or cosmetics have dozens or hundreds of microneedles arranged in a square or circle, microneedle patch tattoos imprint a design that can include letters, numbers, symbols, and images. By arranging the microneedles in a specific pattern, each microneedle acts like a pixel to create a tattoo image in any shape or pattern.

The researchers start with a mold containing microneedles in a pattern that forms an image. They fill the microneedles in the mold with tattoo ink and add a patch backing for convenient handling. The resulting patch is then applied to the skin for a few minutes, during which time the microneedles dissolve and release the tattoo ink. Tattoo inks of various colors can be incorporated into the microneedles, including black-light ink that can only be seen when illuminated with ultraviolet light.

Prausnitz’s lab has been researching microneedles for vaccine delivery for years and realized they could be equally applicable to tattoos. With support from the Alliance for Contraception in Cats and Dogs, Prausnitz’s team started working on tattoos to identify spayed and neutered pets, but then realized the technology could be effective for people, too.

The tattoos were also designed with privacy in mind. The developers even created patches sensitive to environmental factors such as light or temperature changes, where the tattoo will only appear with ultraviolet light or higher temperatures. This provides patients with privacy, revealing the tattoo only when desired.

The study demonstrated that the tattoos could last for at least a year and are likely to be permanent. This also makes them viable cosmetic options for people who want an aesthetic tattoo without the risk of infection or the pain associated with traditional tattoos. Microneedle tattoos could alternatively be loaded with temporary tattoo ink to address short-term needs in medicine and cosmetics.

Microneedle patch tattoos can also be used to encode information in the skin of animals. Rather than clipping the ear or applying an ear tag to animals to indicate sterilization status, a painless and discreet tattoo can be applied instead.

“The goal isn’t to replace all tattoos, which are often works of beauty created by tattoo artists,” Prausnitz said. “Our goal is to create new opportunities for patients, pets, and people who want a painless tattoo that can be easily administered.”

Reference: “Microneedle patch tattoos” by Song Li, Youngeun Kim, Jeong Woo Lee and Mark R. Prausnitz, 14 September 2022, iScience.
DOI: 10.1016/j.isci.2022.105014

Prausnitz has co-founded a company called Micron Biomedical that is developing microneedle patch technology, bringing it further into clinical trials, commercializing it, and ultimately making it available to patients. 

Prausnitz and several other Georgia Tech researchers are inventors of the microneedle patch technology used in this study and have ownership interest in Micron Biomedical. They are entitled to royalties derived from Micron Biomedical’s future sales of products related to the research. These potential conflicts of interest have been disclosed and are overseen by the Georgia Institute of Technology.