This content requires an NEJM.org account. Create a free account now. Already have an account? Sign in . Images in Clinical MedicineFree Preview List of authors. <![CDATA[<![CDATA[<![CDATA[<![CDATA[]]]]]]]]>]]]]]]>]]]]>]]> Select an option below: This content requires an account. Create Account Already have an account? Sign In A 40-year-old man presented with vomiting and diarrhea. Examination was notable … Read more
In this instructional video, Drs. Jane Leopold, Elliott Antman, William Sauer, and Paul Zei provide an overview of the classification and diagnosis of atrial fibrillation, management strategies, and mitigation of stroke risk with anticoagulation therapy. The video also focuses on the new rhythm-control strategy of catheter ablation therapy, with attention to the success rate, potential … Read more
The authors’ full names and academic degrees are as follows: Steven J. Russell, M.D., Ph.D., Roy W. Beck, M.D., Ph.D., Edward R. Damiano, Ph.D., Firas H. El-Khatib, Ph.D., Katrina J. Ruedy, M.S.P.H., Courtney A. Balliro, R.N., C.D.C.E.S., C.R.N.-B.C., Zoey Li, M.S., Peter Calhoun, Ph.D., R. Paul Wadwa, M.D., Bruce Buckingham, M.D., Keren Zhou, M.D., Mark … Read more
This content requires an NEJM.org account. Create a free account now. Already have an account? Sign in . Images in Clinical MedicineFree Preview List of authors. Sakiko Honda, M.D., Ph.D., and Tatsuya Kawasaki, M.D., Ph.D. <![CDATA[<![CDATA[<![CDATA[<![CDATA[]]]]]]]]>]]]]]]>]]]]>]]> Select an option below: This content requires an account. Create Account Already have an account? Sign In A 58-year-old … Read more
Abstract Background The intrathecally administered antisense oligonucleotide tofersen reduces synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with amyotrophic lateral sclerosis (ALS) associated with mutations in SOD1 (SOD1 ALS). Methods Download a PDF of the Research Summary. In this phase 3 trial, we randomly assigned adults with SOD1 ALS … Read more
Abstract Background Transcatheter aortic-valve replacement (TAVR) for the treatment of aortic stenosis can lead to embolization of debris. Capture of debris by devices that provide cerebral embolic protection (CEP) may reduce the risk of stroke. Methods We randomly assigned patients with aortic stenosis in a 1:1 ratio to undergo transfemoral TAVR with CEP (CEP group) … Read more
Abstract Background Early aggressive hydration is widely recommended for the management of acute pancreatitis, but evidence for this practice is limited. Methods Download a PDF of the Research Summary. At 18 centers, we randomly assigned patients who presented with acute pancreatitis to receive goal-directed aggressive or moderate resuscitation with lactated Ringer’s solution. Aggressive fluid resuscitation … Read more
